Similac® 360 Total Care® Gentle Comfort Liquid

Infant formula with iron

Similac® 360 Total Care® Gentle Comfort Liquid

Infant formula with iron

Designed to be our most gentle Similac® 360 Total Care® formula – for immune support, brain development and digestive health, with easy to digest proteins for delicate tummies.

CONTACT A REP

Insurance Coverage May Apply – Learn More.

Hospitals and institutions can order Abbott Nutrition products by calling 800-551-5838, Monday – Friday, 8:00 a.m. to 5:30 p.m. EST.

Established Abbott accounts can order online at e-Abbott.com.

Values listed below are subject to change. Please refer to the product label or packaging for the most current ingredients, allergen and nutrient profile information.

List Number	Item	Market
68452	Similac 360 Total Comfort Care Ready to Feed / 2 fl oz (59 mL) Bottle / 3 x 8 ct	Retail
68449	Similac 360 Total Comfort Care Ready to Feed / 2 fl oz (59 mL) Bottle / 48 ct	Institutional
68454	Similac 360 Total Comfort Care Ready to Feed / 32 fl oz (946 mL) Bottle / 6 ct	Institutional
69187	Similac 360 Total Care Gentle Comfort / 8 fl oz (237 mL) / 4x6 ct	Institutional

Hospitals and institutions can order Abbott Nutrition products by calling 800-551-5838, Monday – Friday, 8:00 a.m. to 5:30 p.m. EST.

100 Cal (5 fl oz)

Nutrition Data

	Amount Per Serving	%DV
Calories	100
Volume, mL	148
Protein, g	2.32
Fat, g	5.4
Carbohydrate, g	10.7
Water, g	133
Linoleic Acid, mg	1000

Vitamins

	Amount Per Serving	%DV
Vitamin A, IU	300
Vitamin D, IU	60
Vitamin E, IU	1.5
Vitamin K, mcg	8
Thiamin (Vitamin B1), mcg	100
Riboflavin (Vitamin B2), mcg	150
Vitamin B6, mcg	60
Vitamin B12, mcg	0.25
Niacin, mcg	1050
Folic Acid (Folacin), mcg	15
Pantothenic Acid, mcg	450
Biotin, mcg	4.4
Vitamin C (Ascorbic Acid), mg	9
Choline, mg	24
Inositol, mg	24

Minerals

	Amount Per Serving	%DV
Calcium, mg	105
Calcium, mEq	5.3
Phosphorus, mg	75
Magnesium, mg	6
Iron, mg	1.8
Zinc, mg	0.75
Manganese, mcg	5
Copper, mcg	90
Iodine, mcg	15
Selenium, mcg	2
Sodium, mg	44
Sodium, mEq	1.9
Potassium, mg	118
Potassium, mEq	3
Chloride, mg	65
Chloride, mEq	1.8

100 Cal (5 fl oz)

Nutrition Data

	Amount Per Serving	%DV
Calories	100
Volume, mL	148
Protein, g	2.32
Fat, g	5.4
Carbohydrate, g	10.7
Water, g	133
Linoleic Acid, mg	1000

Vitamins

	Amount Per Serving	%DV
Vitamin A, IU	300
Vitamin D, IU	60
Vitamin E, IU	1.5
Vitamin K, mcg	8
Thiamin (Vitamin B1), mcg	100
Riboflavin (Vitamin B2), mcg	150
Vitamin B6, mcg	60
Vitamin B12, mcg	0.25
Niacin, mcg	1050
Folic Acid (Folacin), mcg	15
Pantothenic Acid, mcg	450
Biotin, mcg	4.4
Vitamin C (Ascorbic Acid), mg	9
Choline, mg	24
Inositol, mg	24

Minerals

	Amount Per Serving	%DV
Calcium, mg	105
Calcium, mEq	5.3
Phosphorus, mg	75
Magnesium, mg	6
Iron, mg	1.8
Zinc, mg	0.75
Manganese, mcg	5
Copper, mcg	90
Iodine, mcg	15
Selenium, mcg	2
Sodium, mg	44
Sodium, mEq	1.9
Potassium, mg	118
Potassium, mEq	3
Chloride, mg	65
Chloride, mEq	1.8

100 Cal (5 fl oz)

Nutrition Data

	Amount Per Serving	%DV
Calories	100
Volume, mL	148
Protein, g	2.32
Fat, g	5.4
Carbohydrate, g	10.7
Water, g	133
Linoleic Acid, mg	1000

Vitamins

	Amount Per Serving	%DV
Vitamin A, IU	300
Vitamin D, IU	60
Vitamin E, IU	1.5
Vitamin K, mcg	8
Thiamin (Vitamin B1), mcg	100
Riboflavin (Vitamin B2), mcg	150
Vitamin B6, mcg	60
Vitamin B12, mcg	0.25
Niacin, mcg	1050
Folic Acid (Folacin), mcg	15
Pantothenic Acid, mcg	450
Biotin, mcg	4.4
Vitamin C (Ascorbic Acid), mg	9
Choline, mg	24
Inositol, mg	24

Minerals

	Amount Per Serving	%DV
Calcium, mg	105
Calcium, mEq	5.3
Phosphorus, mg	75
Magnesium, mg	6
Iron, mg	1.8
Zinc, mg	0.75
Manganese, mcg	5
Copper, mcg	90
Iodine, mcg	15
Selenium, mcg	2
Sodium, mg	44
Sodium, mEq	1.9
Potassium, mg	118
Potassium, mEq	3
Chloride, mg	65
Chloride, mEq	1.8

1000 mL (1.1 QT)

Nutrition Data

	Amount Per Serving	%DV
Calories	676
Volume, mL	1000
Protein, g	15.68
Fat, g	36.49
Carbohydrate, g	72.3
Water, g	899
Linoleic Acid, mg	6757

Vitamins

	Amount Per Serving	%DV
Vitamin A, IU	2027
Vitamin D, IU	405
Vitamin E, IU	10.1
Vitamin K, mcg	54.1
Thiamin (Vitamin B1), mcg	676
Riboflavin (Vitamin B2), mcg	1014
Vitamin B6, mcg	405
Vitamin B12, mcg	1.69
Niacin, mcg	7095
Folic Acid (Folacin), mcg	101.4
Pantothenic Acid, mcg	3041
Biotin, mcg	29.7
Vitamin C (Ascorbic Acid), mg	60.8
Choline, mg	162.2
Inositol, mg	162.2

Minerals

	Amount Per Serving	%DV
Calcium, mg	709
Calcium, mEq	35.8
Phosphorus, mg	507
Magnesium, mg	40.5
Iron, mg	12.16
Zinc, mg	5.07
Manganese, mcg	33.8
Copper, mcg	608
Iodine, mcg	101
Selenium, mcg	14
Sodium, mg	297
Sodium, mEq	12.8
Potassium, mg	797
Potassium, mEq	20.3
Chloride, mg	439
Chloride, mEq	12.2

1000 mL (1.1 QT)

Nutrition Data

	Amount Per Serving	%DV
Calories	676
Volume, mL	1000
Protein, g	15.68
Fat, g	36.49
Carbohydrate, g	72.3
Water, g	899
Linoleic Acid, mg	6757

Vitamins

	Amount Per Serving	%DV
Vitamin A, IU	2027
Vitamin D, IU	405
Vitamin E, IU	10.1
Vitamin K, mcg	54.1
Thiamin (Vitamin B1), mcg	676
Riboflavin (Vitamin B2), mcg	1014
Vitamin B6, mcg	405
Vitamin B12, mcg	1.69
Niacin, mcg	7095
Folic Acid (Folacin), mcg	101.4
Pantothenic Acid, mcg	3041
Biotin, mcg	29.7
Vitamin C (Ascorbic Acid), mg	60.8
Choline, mg	162.2
Inositol, mg	162.2

Minerals

	Amount Per Serving	%DV
Calcium, mg	709
Calcium, mEq	35.8
Phosphorus, mg	507
Magnesium, mg	40.5
Iron, mg	12.16
Zinc, mg	5.07
Manganese, mcg	33.8
Copper, mcg	608
Iodine, mcg	101
Selenium, mcg	14
Sodium, mg	297
Sodium, mEq	12.8
Potassium, mg	797
Potassium, mEq	20.3
Chloride, mg	439
Chloride, mEq	12.2

1000 mL (1.1 QT)

Nutrition Data

	Amount Per Serving	%DV
Calories	676
Volume, mL	1000
Protein, g	15.68
Fat, g	36.49
Carbohydrate, g	72.3
Water, g	899
Linoleic Acid, mg	6757

Vitamins

	Amount Per Serving	%DV
Vitamin A, IU	2027
Vitamin D, IU	405
Vitamin E, IU	10.1
Vitamin K, mcg	54.1
Thiamin (Vitamin B1), mcg	676
Riboflavin (Vitamin B2), mcg	1014
Vitamin B6, mcg	405
Vitamin B12, mcg	1.69
Niacin, mcg	7095
Folic Acid (Folacin), mcg	101.4
Pantothenic Acid, mcg	3041
Biotin, mcg	29.7
Vitamin C (Ascorbic Acid), mg	60.8
Choline, mg	162.2
Inositol, mg	162.2

Minerals

	Amount Per Serving	%DV
Calcium, mg	709
Calcium, mEq	35.8
Phosphorus, mg	507
Magnesium, mg	40.5
Iron, mg	12.16
Zinc, mg	5.07
Manganese, mcg	33.8
Copper, mcg	608
Iodine, mcg	101
Selenium, mcg	14
Sodium, mg	297
Sodium, mEq	12.8
Potassium, mg	797
Potassium, mEq	20.3
Chloride, mg	439
Chloride, mEq	12.2

Features

Easy-to-digest gentle protein and prebiotics.

Similac® 360 Total Care® Gentle Comfort is an easy-to-digest formula for babies with fussiness and gas who have difficulty tolerating other milk-based formulas due to lactose sensitivity.

Similac® 360 Total Care® Gentle Comfort is designed to be our most gentle infant formula with 5 of the most abundant HMOs found in breast milk and designed to supports baby’s immune system

Similac 360 Total Care Gentle Comfort designed to support your baby’s developing brain, immune system, and digestive health.

Similac® 360 Total Care® Gentle Comfort for immune support.

Similac® 360 Total Care® Gentle Comfort with 5 HMOs is designed to support the growth of beneficial gut bacteria

In a clinical study, infants fed a formula with 5 HMOs had increased growth of beneficial gut bacteria compared to infants fed a formula without HMOs at 6 months of age*.

Infants fed a formula with 5 HMOs Understood on-average 24% more everyday phrases compared to infants fed a formula without HMOs at 12 months of age†.

Similac® 360 Total Care® Gentle Comfort has an exclusive blend of 5 Human Milk Oligosaccharides‡ (HMOs). HMOs are the 3rd most abundant solid component of breast milk. HMOs prebiotics support immune and digestive health.

Our formula has: -Gentle nutrition with easy to digest partially hydrolyzed proteins -Exclusive blend of 5 HMO prebiotics -No palm olein oil -Nucleotides to support the developing immune system

Gluten-free.

Kosher made with dairy ingredients.

Halal.

OptiGRO® is our exclusive blend of DHA, lutein and vitamin E: these important ingredients are found in breast milk. <ul> <li>DHA for brain and eye development.</li> <li>Lutein to support eye health.</li> <li>Vitamin E to support developing cells.</li> </ul>

Precautions

Never use a microwave oven to warm formula. Serious burns can result.

Not for infants or children with galactosemia.

*In a clinical study, infants fed Similac 360 Total Care with 5 HMOs had growth of a group of 5 species of infant-specific Bifidobacterium like breastfed infants and greater than infants fed a formula without HMOs at 6 months of age (Niemiro et al. 2025). Not studied in Similac 360 Total Care Gentle Comfort.

†Measured by parent-reported assessment tool (MacArthur-Bates Communicative Development Inventories, Phrases Understood) at 12 months of age. Infants fed a formula without HMOs had fewer phrases understood than infants fed Similac 360 Total Care while breastfed infants were not significantly different from either group (Reverri et al. 2025). Not studied in Similac 360 Total Care Gentle Comfort.

‡Not from human milk.

Unflavored Liquid

Water, Corn Syrup Solids, Whey Protein Hydrolysate, High Oleic Safflower Oil, Sugar, Soy Oil, Coconut Oil, Less than 0.5% of: Human Milk Oligosaccharide* (2'-Fucosyllactose, Lacto-N-Tetraose, 3-Fucosyllactose, 6'-Sialyllactose, 3'-Sialyllactose), Schizochytrium Sp. Oil †, M. Alpina Oil ‡, Beta-Carotene, Lutein, Soy Lecithin, Calcium Citrate, Potassium Phosphate, Calcium Phosphate, Carrageenan, Ascorbic Acid, Magnesium Chloride, Monoglycerides, Salt, Inositol, Choline Chloride, Potassium Hydroxide, Potassium Chloride, Ferrous Sulfate, Choline Bitartrate, Taurine, Zinc Sulfate, L-Carnitine, d-Alpha-Tocopheryl Acetate, Niacinamide, Calcium Pantothenate, Potassium Citrate, Vitamin A Palmitate, Copper Sulfate, Thiamine Hydrochloride, Riboflavin , Pyridoxine Hydrochloride, Folic Acid, Manganese Sulfate, Potassium Iodide, Phylloquinone, Biotin, Sodium Selenate, Vitamin D3, Vitamin B 12, Nucleotides (Adenosine 5'-Monophosphate, Cytidine 5'-Monophosphate, Disodium Guanosine 5'-Monophosphate, Disodium Uridine 5'-Monophosphate)
*HMO, not from human milk † Source of DHA
‡ Source of ARA.

Water, Corn Syrup Solids, Whey Protein Hydrolysate, High Oleic Safflower Oil, Sugar, Soy Oil, Coconut Oil, Less than 0.5% of: Human Milk Oligosaccharide* (2'-Fucosyllactose, Lacto-N-Tetraose, 3-Fucosyllactose, 6'-Sialyllactose, 3'-Sialyllactose), Schizochytrium Sp. Oil †, M. Alpina Oil ‡, Beta-Carotene, Lutein, Soy Lecithin, Calcium Citrate, Potassium Phosphate, Calcium Phosphate, Carrageenan, Ascorbic Acid, Magnesium Chloride, Monoglycerides, Salt, Inositol, Choline Chloride, Potassium Hydroxide, Potassium Chloride, Ferrous Sulfate, Choline Bitartrate, Taurine, Zinc Sulfate, L-Carnitine, d-Alpha-Tocopheryl Acetate, Niacinamide, Calcium Pantothenate, Potassium Citrate, Vitamin A Palmitate, Copper Sulfate, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Manganese Sulfate, Potassium Iodide, Phylloquinone, Biotin, Sodium Selenate, Vitamin D3, Vitamin B 12, Nucleotides (Adenosine 5'-Monophosphate, Cytidine S'-Monophosphate, Disodium Guanosine S'-Monophosphate, Disodium Uridine S'-Monophosphate)
*HMO, not from human milk
† Source of DHA
‡ Source of ARA

Water, Corn Syrup Solids, Whey Protein Hydrolysate, High Oleic Safflower Oil, Sugar, Soy Oil, Coconut Oil, Less than 0.5% of: Human Milk Oligosaccharide* (2'-Fucosyllactose, Lacto-N-Tetraose, 3-Fucosyllactose, 6'-Sialyllactose, 3'-Sialyllactose), Schizochytrium Sp. Oil †, M. Alpina Oil ‡, Beta-Carotene, Lutein, Soy Lecithin, Calcium Citrate, Potassium Phosphate, Calcium Phosphate, Carrageenan, Ascorbic Acid, Magnesium Chloride, Monoglycerides, Salt, Inositol, Choline Chloride, Potassium Hydroxide, Potassium Chloride, Ferrous Sulfate, Choline Bitartrate, Taurine, Zinc Sulfate, L-Carnitine, d-Alpha-Tocopheryl Acetate, Niacinamide, Calcium Pantothenate, Potassium Citrate, Vitamin A Palmitate, Copper Sulfate, Thiamine Hydrochloride, Riboflavin , Pyridoxine Hydrochloride, Folic Acid, Manganese Sulfate, Potassium Iodide, Phylloquinone, Biotin, Sodium Selenate, Vitamin D3, Vitamin B 12, Nucleotides (Adenosine 5'-Monophosphate, Cytidine 5'-Monophosphate, Disodium Guanosine 5'-Monophosphate, Disodium Uridine 5'-Monophosphate)

*HMO, not from human milk
† Source of DHA
‡ Source of ARA.

CONTAINS MILK AND SOY INGREDIENTS.

Preparation

Instructions for Use:

Your baby's health depends on carefully following these directions. Failure to follow these directions could result in severe harm. Ask your baby's doctor if you need to boil (sterilize) bottle, nipple and ring before use.

Use by Date on Container. Do not add water. Do not use if band a round cap or inner foil seal is damaged.

2 fl oz bottle

Do not use if breakaway ring is missing or broken.
Use as directed by a doctor.
Ready to feed.
Shake very well.
Open; attach clean single use nipple and ring; use sterile nipple and ring if directed.
Discard one hour after oral feeding begins
Store unopened at room temperature; avoid extreme temperatures and exposure to light.

8 fl oz bottle

Shake very well
DO NOT USE if breakaway ring is missing or broken.
Twist off cap.
Twist on clean nipple and ring.
For use in a different feeding container (cup or bottle) :
• Ask your baby's doctor if you need to boil (sterilize) the empty bottles before adding formula.
• Pour desired amount into clean feeding container. Recap bottle, refrigerate, and use within 48 hours.
Once feeding begins, use with in 1 hour or discard.
Store unopened at room temperature; avoid extreme temperatures. Do not reuse this bottle. Protect from light.

1 QT bottle

Do not use if band around cap or inner foil seal is damaged.
Shake very well before each use.
Remove protective band; twist off and clean cap.
Invert cap; press down to pierce foil, then turn cap a half turn.
Remove foil.
Pour formula into bottle; attach clean nipple.
Once feeding begins, use with in 1 hour or discard.
Store Unopened Container at room temperature; avoid extreme temperatures Opened Container: Recap, refrigerate, and feed with in 3 Days. Do not reuse container.
Prepared Unfed Bottles: Cap, refrigerate, and feed with in 2 days.